چکیده

Background: The use Monte Carlo GATE code, as a simulation toolkit, is a great way for doing medical dosimetry. In patients undergoing 131I therapy, using of pretreatment with lithium and it’s beneficiary assessment in thyroid cancer patients before Radio-iodine therapy (RIT) is proposed to improve the results of therapy in terms of higher radiation to thyroid tissue and limiting extra-thyroid irradiation. Methods: The beta and gamma irradiated to the thyroid gland and lungs of a female New Zealand 3 kg rabbit was simulated employing Monte Carlo GATE code. The study design was before-after lithium pretreatment. The rabbit was treated with 280 µCi Iodine-131 orally with and without pretreatment with 60 mg per day (2×30 mg) lithium for 14 days. SPECT/CT imaging was done 24 hours after RIT providing the distribution and attenuation maps for simulation. The S values were calculated and compared between the rabbit prepared with and without lithium before RIT by analysis of covariance designing general linear models. Results: The thyroid to lungs ratio of the S-values with and without lithium pretreatment was 11.1 vs. 19.2 for beta and 5.1 vs. 9.3 for gamma rays respectively. Conclusion: Lithium demonstrated no improvement in radioiodine uptake in rabbit thyroid tissue. Pretreatment of hyperthyroid and cancerous patients with lithium before RIT, which is backed to old literature, should be more evaluate.

کليدواژه ها

Monte Carlo simulation, dosimetry, lithium, 131I, GATE code

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شیما یاوری , 1400 , ارزیابی اثر لیتیم بر جذب ید۱۳۱ در بافت تیرویید خرگوش با استفاده از شبیه سازی مونت کارلو کد گیت به عنوان ابزار شبیه سازی , نخستین همایش بین المللی و سومین همایش ملی ریاضیات زیستی