چکیده

Background: Ovarian Cancer (OC) as a common gynecologic cancer according to mortality rate has the seventh rank among women in the world.This study aimed to identify risk factors associated with OC survival in Yazd, Iran. Methods: In this observational retrospective cohort study, the medical records of 150 patients who were definitively diagnosed with OC at Shah Vali Hospital, Yazd, Iran from 1999 to 2018 were investigated. The Kaplan–Meier estimator and the Cox proportional hazard model with hazard ratio and the log-rank test was used to data analysis. All statistical analyses were done in R 4.0.5, package survival. 5% was considered as significant level. Results: 60.77% (91 people) of patients were under 60 years old. 32.7% (49 people) were in stage III of disease. 62% (93 people) did not have ascites, 67.3% (101 people) had disease-free survival more than 65 months. 45 (30%) of 150 patients were dead. Median survival time was 96 months (95% CI∶57.20 to 134.79), one, three, five, and ten years survival rates were 83,73,55and 33 months; respectively. log-rank test results showed there was a significant difference between age, stage,ascites, disease-free survival, Treatment method, CA125 after and before treatment (p<0.05). Cox proportional hazard model result showed ascites (HRadj =3.89, 95%CI:1.35to11.15,P =0.01) and DFS (HRadj =23.52, 95 % CI:4.21to128.33, p = <0.001) as significant covariates. Conclusion: The results of our study showed that disease-free survival and ascites are the main risk factors for OC and paying attention to them will be effective in increasing patient survival.

کليدواژه ها

Keywords: Ovarian Cancer, Survival, Cox proportional hazard, Iran

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حسین فلاح زاده , 1400 , بررسی بقای بیماران مبتلا به سرطان تخمدان در شهر یزد ایران طی سال‌های 1378 تا 1397 , نخستین همایش بین المللی و سومین همایش ملی ریاضیات زیستی